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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Organization of Genes02:07

Organization of Genes

Overview
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Statgraphics01:10

Statgraphics

Statgraphics is a comprehensive statistical software suite designed for both basic and advanced data analysis. Originating in 1980 at Princeton University under Dr. Neil W. Polhemus, it was one of the pioneering tools for statistical computing on personal computers, with its public release in 1982 marking an early milestone in data science software. Over the years, it has evolved into a robust platform for data science, offering tools for regression analysis, ANOVA, multivariate statistics,...

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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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Published on: August 16, 2017

Conceptualizing a Genomics Software Institute (GSI).

Jack A Gilbert, Charlie Catlett, Narayan Desai

    Standards in Genomic Sciences
    |June 8, 2012
    PubMed
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    Area of Science:

    • Microbial ecology and bioinformatics.
    • Environmental science and biodiversity research.

    Background:

    • The 'omics revolution provides unprecedented data on microbial biomass and biodiversity.
    • Current research generates vast amounts of sequence, protein, and metabolite data.

    Purpose of the Study:

    • To address the need for a collaborative framework for developing and exchanging predictive ecosystem models in microbial ecology.
    • To outline a strategic plan for a Genomic Software Institute (GSI) to facilitate this framework.

    Main Methods:

    • Discussing the requirements for a data and metadata framework, including transparency, interoperability, validation, curation, and search capabilities.
    • Highlighting the need for APIs for modeling and analysis tools.
    • Emphasizing community interaction and leveraging existing efforts like the Genomic Standards Consortium (GSC).

    Main Results:

    • Identifying the lack of a standardized framework as a key impediment to macro-scale microbial ecology research.
    • Proposing the establishment of a Genomic Software Institute (GSI) to foster a collaborative environment.
    • Outlining essential components for a successful framework, including data standards and accessible tools.

    Conclusions:

    • A community-driven framework is crucial for advancing microbial ecology by enabling the development and sharing of predictive ecosystem models.
    • The proposed Genomic Software Institute (GSI) aims to consolidate efforts and provide necessary infrastructure for data analysis and modeling.
    • Enhanced collaboration and standardized practices are essential to fully leverage 'omics data for understanding global microbial biodiversity and function.