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Published on: May 15, 2012
Cross metathesis assisted solid-phase synthesis of glycopeptoids
Sharaf Nawaz Khan1, Arim Kim, Robert H Grubbs
1Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, South Korea.
Abstract:
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds.
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