Related Experiment Video
Updated: May 21, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Multistage pH-responsive liposomes for mitochondrial-targeted anticancer drug delivery
Ran Mo1, Qiong Sun, Jingwei Xue
1Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Abstract:
Zwitterionic oligopeptide liposomes (HHG2C(18)-L) containing a smart lipid (1,5-dioctadecyl-L-glutamyl 2-histidyl-hexahydrobenzoic acid, HHG2C(18)) are developed to overcome the barriers faced by anticancer drugs on the route from the site of injection into the body to the final antitumor target within transport steps with multiple physiological and biological barriers. HHG2C(18)-L show the multistage pH-responsive to the tumor cell (the mitochondria in this case). Their multistage pH response leads to more effective entry of the tumor cell, improved escape from the endolysosomes, and accumulation at the mitochondria (see picture).
Related Concept Videos
Modified-Release Drug Delivery Systems: Site-Targeted
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Targeted Cancer Therapies
There are several types of targeted therapies against specific...

