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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Protein-losing enteropathy in ulcerative colitis.

Ryan Ungaro1, Mark W Babyatsky, Hongfa Zhu

  • 1Department of Internal Medicine, The Mount Sinai School of Medicine, New York, N.Y., USA.

Case Reports in Gastroenterology
|June 9, 2012
PubMed
Summary
This summary is machine-generated.

Protein-losing enteropathy (PLE), a complication of ulcerative colitis (UC), can cause severe weight loss and low albumin. Surgical removal of the colon (procto-colectomy) effectively treated PLE in a UC patient.

Keywords:
Procto-colectomyProtein-losing enteropathyUlcerative colitis

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Clinical Case Study

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Protein-losing enteropathy (PLE) is a rare but serious complication of UC.

Observation:

  • A 26-year-old male with UC experienced significant weight loss (50 lbs) and severe hypoalbuminemia (1.2 g/dl) during a UC flare.
  • Despite clinical UC control with steroids, symptoms persisted, complicated by deep vein thrombosis and pulmonary embolism.

Findings:

  • Diagnosis of PLE was confirmed via elevated stool alpha-1-antitrypsin clearance.
  • The patient's persistent symptoms and complications significantly improved after procto-colectomy.

Implications:

  • This case highlights PLE as a critical differential diagnosis in UC patients with unexplained weight loss and hypoalbuminemia.
  • Surgical intervention (procto-colectomy) can be an effective treatment for refractory PLE in UC.
  • Early recognition and management of PLE are crucial to prevent severe complications like thromboembolism.