Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Packaging

DNA Packaging

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An intracellular release peptide display technology unveils an antimicrobial peptide with low probability for resistance development.

iScience·2025

Same author

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes.

Scientific reports·2016

Same author

Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses.

Frontiers in microbiology·2016

Same author

The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species.

Microbiology (Reading, England)·2015

Same author

Chaperonins fight aminoglycoside-induced protein misfolding and promote short-term tolerance in Escherichia coli.

The Journal of biological chemistry·2013

Same author

To DNA, all information is equal.

Artificial DNA, PNA & XNA·2012

Search research articles

Related Experiment Video

Updated: May 21, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

A DNA nanocapsule with aptamer-controlled open-closure function for targeted delivery.

Thomas Bentin¹

¹Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen, Denmark. bentin@sund.ku.dk

Artificial DNA, PNA & XNA

|June 9, 2012

Summary

Researchers developed a DNA capsule using DNA origami for targeted molecular delivery. This aptamer-controlled capsule precisely delivers cargo to specific cell surfaces.

Keywords:

DNA origami aptamer delivery nanocapsule nanoscience

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Related Experiment Videos

Last Updated: May 21, 2026

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

DNA nanotechnology enables the construction of complex nanoscale structures.
Targeted delivery systems are crucial for precise therapeutic applications.

Purpose of the Study:

To engineer a DNA capsule capable of logic-gated molecular cargo delivery.
To integrate aptamer-controlled target sensing for specific cell surface recognition.

Main Methods:

Fabrication of a DNA capsule using a 7308-base single-stranded DNA scaffold and 196 staple oligonucleotides.
Incorporation of aptamers for specific binding to target cell surface receptors.

Main Results:

Successful construction of a functional DNA capsule via DNA origami.
Demonstration of aptamer-mediated targeting to specific cell surfaces.
Logic-gated release of molecular cargo.

Conclusions:

The developed DNA capsule represents a novel platform for targeted molecular delivery.
Aptamer-controlled sensing enhances the specificity of cargo delivery.
This technology holds potential for advanced therapeutic and diagnostic applications.