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Updated: May 21, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Floppy eyelid syndrome and obstructive sleep apnoea]
M Karhanová1, M Hobzová, K Maresová
1Ocní Klinika LF UP a FN, Olomouc. marta.karhanova@fnol.cz
Floppy eyelid syndrome (FES) is a rare condition often linked to obstructive sleep apnea (OSA). Early FES diagnosis can indicate undiagnosed OSA, highlighting the importance of recognizing this often-overlooked eye condition.
Area of Science:
- Ophthalmology
- Sleep Medicine
- Genetics
Context:
- Floppy eyelid syndrome (FES) is a rare condition often associated with systemic diseases.
- Obstructive sleep apnea (OSA) is a significant sleep-related breathing disorder frequently comorbid with FES.
- FES is characterized by an easily evertable, enlarged upper eyelid, often unilateral and related to sleeping position.
Purpose:
- To report on Floppy Eyelid Syndrome (FES), a condition frequently overlooked in eye clinics.
- To summarize the author's experience in diagnosing and treating FES.
- To emphasize the diagnostic significance of FES for identifying concurrent obstructive sleep apnea (OSA).
Summary:
- FES presents with a characteristic floppy upper eyelid, ptosis, and potential ocular surface disease.
- The condition's laterality often correlates with the patient's preferred sleeping side.
- Associated symptoms include chronic conjunctivitis and corneal disorders.
Impact:
- Early and accurate diagnosis of FES can serve as a crucial indicator for undiagnosed OSA.
- Recognizing FES prompts further investigation into sleep-related breathing disorders.
- Improved patient outcomes through integrated diagnosis and management of FES and OSA.
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