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Allosteric modulation of protease-activated receptor signaling

I Canto1, U J K Soh, J Trejo

  • 1Department of Pharmacology, School of Medicine, University of California, San Diego, Biomedical Sciences Building, Room 3044A, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA. joanntrejo@ucsd.edu

Mini Reviews in Medicinal Chemistry
|June 12, 2012
PubMed
Summary

Protease-activated receptors (PARs) are GPCRs activated by proteolysis. Novel research reveals PARs can be differentially activated, leading to distinct cellular responses through allosteric modulation.

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