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Updated: May 21, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Antimicrobial resistance of Staphylococcus pseudintermedius.

Kristina Kadlec¹, Stefan Schwarz

¹Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Höltystraße 10, 31535 Neustadt-Mariensee, Germany. kristina.kadlec@fli.bund.de

Veterinary Dermatology

|June 12, 2012

Summary

Meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections are a growing concern in veterinary medicine. This review highlights the genetic basis of antimicrobial resistance in MRSP, focusing on transposon-mediated gene transfer.

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Area of Science:

Veterinary Microbiology
Antimicrobial Resistance
Molecular Biology

Background:

Staphylococcus pseudintermedius (S. pseudintermedius) is a major pathogen in dogs, causing various infections.
Meticillin-resistant S. pseudintermedius (MRSP) strains exhibit resistance to multiple antimicrobial agents used in veterinary medicine.
The Staphylococcus intermedius group (SIG) includes S. pseudintermedius, S. intermedius, and S. delphini.

Purpose of the Study:

To review the genetic mechanisms underlying antimicrobial resistance in S. pseudintermedius and other SIG members.
To summarize known resistance genes and their association with mobile genetic elements.
To update knowledge on resistance-mediating mutations in S. pseudintermedius.

Main Methods:

Literature review of studies on antimicrobial resistance in SIG species.
Analysis of genetic data related to resistance genes and mobile genetic elements.
Compilation of information on resistance-mediating mutations.

Main Results:

S. pseudintermedius is the primary pathogenic species within the SIG.
MRSP isolates show resistance to most approved veterinary antimicrobials.
Transposon-borne resistance genes, integrated into chromosomal DNA, are prevalent in S. pseudintermedius, unlike plasmid-located genes common in other staphylococci.

Conclusions:

Antimicrobial resistance in S. pseudintermedius is largely mediated by transposon-associated genes.
Understanding these genetic mechanisms is crucial for combating MRSP infections in animals and potentially humans.
The distinct preference for transposon-mediated resistance in S. pseudintermedius warrants further investigation.