Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors
Theresa A Lansdell1, Sandra O'Reilly, Tracey Woolliscroft
1Department of Chemistry, Michigan State University, East Lansing, MI, USA.
Bioorganic & Medicinal Chemistry Letters
|June 12, 2012
Abstract:
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
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