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Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
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Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Botryomycosis.

Carmen Padilla-Desgarennes1, Denisse Vázquez-González, Alexandro Bonifaz

  • 1Mycology Section, Centro Dermatológico Dr. Ladislao de la Pascua, Mexico, DF, Mexico.

Clinics in Dermatology
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Botryomycosis is a chronic bacterial infection causing grains. Diagnosis requires clinical suspicion and microbiologic studies for effective treatment.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Immunology

Background:

  • Botryomycosis is a chronic, granulomatous infectious disease characterized by grain formation.
  • Causative agents include several bacterial genera, with pathogenesis involving low virulence, intermediate inoculum, and host immunologic status.
  • The Splendore-Hoeppli phenomenon is implicated in grain formation and the characteristic antigen-antibody reaction.

Purpose of the Study:

  • To elucidate the key factors and pathogenic mechanisms of botryomycosis.
  • To highlight the diagnostic approaches for botryomycosis.
  • To emphasize the importance of microbiologic studies in guiding treatment.

Main Methods:

  • Review of existing literature on botryomycosis pathogenesis and diagnosis.
  • Analysis of clinical and microbiological findings associated with the disease.
  • Discussion of the role of the Splendore-Hoeppli phenomenon.

Main Results:

  • Botryomycosis development is multifactorial, influenced by bacterial virulence, inoculum size, and host immunity.
  • The Splendore-Hoeppli phenomenon is a key feature in the disease's pathology.
  • Accurate diagnosis relies on clinical suspicion coupled with essential microbiologic investigations.

Conclusions:

  • Effective management of botryomycosis necessitates identification of the causative agent and antimicrobial susceptibility testing.
  • Understanding the pathogenesis, including the Splendore-Hoeppli phenomenon, aids in diagnosis and treatment strategies.
  • Botryomycosis requires a comprehensive diagnostic approach combining clinical and laboratory methods for successful outcomes.