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Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Updated: May 21, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Cutaneous zygomycosis.

Alexandro Bonifaz1, Denisse Vázquez-González, Andrés Tirado-Sánchez

  • 1Department of Mycology, General Hospital of Mexico, Dr. Balmis 148, Colonia Doctores, Mexico City, Mexico. a_bonifaz@yahoo.com.mx

Clinics in Dermatology
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Cutaneous zygomycosis, a fungal skin infection, affects diabetics and the immunosuppressed. Early diagnosis and treatment with debridement and amphotericin B improve outcomes for primary cases.

Related Experiment Videos

Last Updated: May 21, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Cutaneous zygomycosis is a rare but serious fungal infection affecting the skin.
  • It primarily impacts individuals with uncontrolled diabetes mellitus and those who are immunosuppressed.
  • The infection presents in two distinct clinical forms: primary and secondary.

Purpose of the Study:

  • To describe the clinical characteristics, diagnosis, and treatment of cutaneous zygomycosis.
  • To differentiate between primary and secondary forms of the infection.
  • To highlight the importance of early diagnosis and appropriate management.

Main Methods:

  • Diagnosis relies on direct potassium hydroxide (KOH) examination of skin scrapings.
  • Fungal identification is confirmed through fungal culture and skin biopsy.
  • Clinical presentation and patient history are crucial for differentiating forms.

Main Results:

  • Primary cutaneous zygomycosis, often from trauma, presents with necrotic lesions and has a good prognosis if treated early.
  • Secondary cutaneous zygomycosis, an extension of rhinocerebral disease, begins as a palpebral fistula and progresses to necrotic lesions with a poor prognosis.
  • Fungal identification via KOH, culture, and biopsy confirms the diagnosis.

Conclusions:

  • Early diagnosis and prompt treatment are critical for improving outcomes in cutaneous zygomycosis.
  • Primary cutaneous zygomycosis requires surgical debridement and amphotericin B.
  • Secondary cutaneous zygomycosis necessitates treatment with amphotericin B and/or posaconazole.