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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
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Published on: December 19, 2014

Subcutaneous phaeohyphomycosis (mycotic cyst).

Rafael Isa-Isa1, Carlos García, Mariel Isa

  • 1Instituto Dermatológico y Cirugía de Piel Dr. Huberto Bogaert Díaz, Santo Domingo, Dominican Republic.

Clinics in Dermatology
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PubMed
Summary

Phaeohyphomycosis, fungal infections from melanized fungi, present varied clinical forms. Surgical excision is the primary treatment for mycotic cysts, with antifungals for recurrent or severe cases.

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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Phaeohyphomycosis encompasses fungal infections caused by pigmented fungi.
  • Histopathology reveals septate hyphae, pseudohyphae, and yeasts.
  • Common causative agents include Exophiala and Wangiella species.

Purpose of the Study:

  • To describe the clinical spectrum and histopathological features of phaeohyphomycosis.
  • To highlight the presentation and management of mycotic cysts.
  • To outline treatment strategies based on host immunity and disease severity.

Main Methods:

  • Review of clinical presentations and etiological agents.
  • Histopathological analysis of KOH examinations and biopsy specimens.
  • Evaluation of treatment outcomes.

Main Results:

  • Clinical manifestations range from superficial to systemic infections.
  • Mycotic cysts are asymptomatic subcutaneous nodules, often on extremities.
  • KOH and biopsy show pigmented yeasts, pseudohyphae, and hyphae, with abscess or granuloma formation.

Conclusions:

  • Phaeohyphomycosis presents diverse clinical forms influenced by host immunity.
  • Surgical excision is the primary treatment for mycotic cysts.
  • Antifungal therapy is crucial for recurrent infections and immunocompromised individuals.