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Structure and Function of Platelets01:18

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Introduction to Hemostasis01:05

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Platelets and cytokines: How and why?

O Garraud1, H Hamzeh-Cognasse, F Cognasse

  • 1Établissement français du sang Auvergne-Loire, 25, boulevard Pasteur, 42023 Saint-Étienne cedex 02, France. olivier.garraud@efs.sante.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|June 12, 2012
PubMed
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Platelet transfusions, vital for deficiencies, can cause complications due to platelet activation and release of inflammatory molecules. Understanding these mechanisms can improve transfusion safety.

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Last Updated: May 21, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Published on: May 23, 2025

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Published on: November 8, 2024

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Platelet components are essential therapeutics for platelet deficiencies with no substitutes.
  • Platelet transfusions are associated with higher complication rates compared to other blood products.
  • Complications stem from molecules secreted by activated platelets, including cytokines and chemokines.

Purpose of the Study:

  • To review current knowledge on platelet components as sources of cytokines and biological response modifiers.
  • To discuss factors contributing to platelet activation during transfusion.
  • To explore strategies for enhancing blood product quality and patient safety.

Main Methods:

  • Literature review of scientific articles on platelet function, activation, and transfusion reactions.
  • Analysis of mechanisms underlying platelet activation in the context of immune responses and preparation processes.
  • Synthesis of current understanding of platelet-derived mediators.

Main Results:

  • Platelets release various cytokines and biological response modifiers upon activation.
  • Platelet activation during transfusion may be influenced by donor-recipient interactions, preparation methods, and donor immune sensing.
  • These released molecules contribute to transfusion-related adverse events.

Conclusions:

  • Platelet components are a source of bioactive molecules that can cause transfusion complications.
  • Further research into platelet activation pathways is needed to mitigate risks.
  • Improving platelet preparation and understanding donor factors can enhance transfusion safety.