Related Experiment Video
Updated: May 21, 2026
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Xanthomatous hypophysitis
M Niyazoglu1, O Celik, D V Bakkaloglu
1Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Istanbul, Cerrahpasa Medical School, Endokrinoloji-Metabolizma ve Diyabet Bilim Dali, Cerrahpasa 34303, Istanbul, Turkey.
Summary
Xanthomatous hypophysitis (XH), a rare pituitary condition, presents with specific symptoms and imaging findings. Early consideration of XH in pituitary lesion diagnosis is crucial for appropriate patient management.
Area of Science:
- Endocrinology
- Pathology
- Radiology
Background:
- Xanthomatous hypophysitis (XH) is an uncommon primary inflammation of the pituitary gland.
- Differential diagnosis for pituitary lesions includes Erdheim-Chester disease and Langerhans cell histiocytosis.
Observation:
- A 39-year-old woman presented with headache, menstrual irregularities, and galactorrhea.
- MRI revealed a 1cm pituitary lesion with a central cystic/necrotic area.
- Histology showed foamy histiocytes and necrosis; immunohistochemistry was positive for CD68 and negative for CD1a and S100.
Findings:
- The patient was diagnosed with Xanthomatous Hypophysitis based on clinical, imaging, and histological findings.
- Glucocorticoid treatment was initiated for the diagnosed XH.
Implications:
- Xanthomatous hypophysitis should be included in the differential diagnosis of pituitary lesions.
- The rarity of XH complicates accurate assessment of treatment efficacy.
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