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Updated: May 21, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Xanthomatous hypophysitis.

M Niyazoglu¹, O Celik, D V Bakkaloglu

¹Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Istanbul, Cerrahpasa Medical School, Endokrinoloji-Metabolizma ve Diyabet Bilim Dali, Cerrahpasa 34303, Istanbul, Turkey.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|June 12, 2012

Summary

Xanthomatous hypophysitis (XH), a rare pituitary condition, presents with specific symptoms and imaging findings. Early consideration of XH in pituitary lesion diagnosis is crucial for appropriate patient management.

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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Area of Science:

Endocrinology
Pathology
Radiology

Background:

Xanthomatous hypophysitis (XH) is an uncommon primary inflammation of the pituitary gland.
Differential diagnosis for pituitary lesions includes Erdheim-Chester disease and Langerhans cell histiocytosis.

Observation:

A 39-year-old woman presented with headache, menstrual irregularities, and galactorrhea.
MRI revealed a 1cm pituitary lesion with a central cystic/necrotic area.
Histology showed foamy histiocytes and necrosis; immunohistochemistry was positive for CD68 and negative for CD1a and S100.

Findings:

The patient was diagnosed with Xanthomatous Hypophysitis based on clinical, imaging, and histological findings.
Glucocorticoid treatment was initiated for the diagnosed XH.

Implications:

Xanthomatous hypophysitis should be included in the differential diagnosis of pituitary lesions.
The rarity of XH complicates accurate assessment of treatment efficacy.