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Related Concept Videos

Export of Misfolded Proteins out of the ER01:32

Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Electron Paramagnetic Resonance (EPR) Spectroscopy: Organic Radicals01:17

Electron Paramagnetic Resonance (EPR) Spectroscopy: Organic Radicals

Ideally, an unpaired electron shows a single peak in the EPR spectrum due to the transition between the two spin energy states. However, coupling interactions can occur between the spins of the unpaired electron and any neighboring spin-active nuclei. This hyperfine coupling results in hyperfine splitting, where the EPR signal is split into multiplets. The signals split into 2nI + 1 peaks, where n is the number of equivalent nuclei and I is the nuclear spin. These splitting patterns provide...
The Unfolded Protein Response01:37

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
Methods of Documentation VII: EMR01:30

Methods of Documentation VII: EMR

Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare settings,...

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Related Experiment Video

Updated: May 21, 2026

High Density Event-related Potential Data Acquisition in Cognitive Neuroscience
08:33

High Density Event-related Potential Data Acquisition in Cognitive Neuroscience

Published on: April 16, 2010

From ERPs to academics.

Charles H Hillman1, Matthew B Pontifex, Robert W Motl

  • 1Department of Kinesiology & Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. chhillma@illinois.edu

Developmental Cognitive Neuroscience
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

The P3 brainwave component, reflecting attention and inhibition, may predict reading and arithmetic skills in children. This electrophysiological measure shows potential as a biomarker for academic achievement.

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Last Updated: May 21, 2026

High Density Event-related Potential Data Acquisition in Cognitive Neuroscience
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Published on: May 31, 2018

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Educational Psychology

Background:

  • Standardized tests are common for assessing scholastic success.
  • Previous research linked academic achievement to cognitive functions like intelligence, working memory, and inhibition.
  • Electrophysiological correlates (ERP) of academic achievement, specifically the P3 component, were not well-documented.

Purpose of the Study:

  • To investigate the relationship between academic achievement and the P3 event-related potential (ERP) component in children.
  • To determine if P3 amplitude could serve as a biomarker for scholastic success.

Main Methods:

  • A sample of 105 children participated in the study.
  • The Wide Range Achievement Test - 3rd edition (WRAT-3) was used to assess academic aptitude in reading, spelling, and arithmetic.
  • Event-related potentials (ERPs), specifically the P3 component, were recorded during a Go/NoGo task.

Main Results:

  • P3 amplitude significantly predicted reading and arithmetic achievement, independent of IQ and school grade.
  • No significant relationship was found between P3 amplitude and spelling achievement.
  • These findings suggest P3 reflects cognitive processes crucial for academic success.

Conclusions:

  • The P3 component, associated with attentional and inhibitory processes, may be a valuable biomarker for academic achievement in childhood.
  • Electrophysiological measures like P3 offer novel insights into the neural underpinnings of scholastic success.
  • Further research is warranted to explore the P3's role across different academic domains and age groups.