Related Experiment Video
Updated: May 21, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives
N M Rahmoun1, Z Boucherit-Otmani, K Boucherit
1Laboratoire Antibiotiques Antifongiques, Physico-Chimie, Synthèse et Activité Biologique, Département de Biologie, Faculté des Sciences, Tlemcen University, 13000 Tlemcen, Algeria. nagrah113@hotmail.com
Introduction:
Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro.
Methods:
The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recommendations of the Clinical and Laboratory Standards Institute.
Results:
Two compounds (P05 et P06) presented a good antibacterial effectiveness against two gram-positive bacteria. No antifungal potency was observed against the three Candida albicans strains used in the test.
Conclusion:
Our results prove that the introduction of substituents on ketone function position 4 decreased the antimicrobial properties of the synthetized compounds.
Related Concept Videos
Antifungal Agents
Inhibitors of Bacterial DNA Synthesis
Gene Regulation in Microbial Communities: Quorum Sensing
Antimicrobial Effectiveness
Local Anesthetics: Chemistry and Structure-Activity Relationship
Aryldiazonium Salts to Azo Dyes: Diazo Coupling

