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Updated: May 21, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Canadian Headache Society guideline for migraine prophylaxis
Tamara Pringsheim1, W Jeptha Davenport, Gordon Mackie
1University of Calgary and the Hotchkiss Brain Institute, Calgary, AB, Canada.
Summary
Choosing migraine prophylactic medication involves considering efficacy, side effects, and patient history. This guideline offers evidence-based recommendations for episodic migraine management.
Area of Science:
- Neurology
- Pharmacology
- Evidence-Based Medicine
Background:
- Episodic migraine affects a significant patient population.
- Selecting appropriate prophylactic medication is crucial for effective migraine management.
- Current evidence and expert consensus guide treatment decisions.
Purpose of the Study:
- To guide practitioners in selecting optimal prophylactic medications for episodic migraine.
- To provide evidence-based recommendations for migraine prophylaxis.
- To consolidate current medical literature and expert opinions.
Main Methods:
- Comprehensive search of randomized controlled trials (RCTs) and Cochrane reviews.
- Grading of studies using US Preventive Services Task Force criteria.
- Application of GRADE principles for recommendation grading and expert consensus for data gaps.
Main Results:
- Eleven prophylactic drugs strongly recommended; six received weak recommendations.
- Medication choice hinges on efficacy, side effects, migraine features, and comorbidities.
- Developed tailored strategies for diverse patient profiles, including first-time prophylaxis, low side-effect needs, and refractory cases.
Conclusions:
- Robust evidence supports multiple prophylactic medications for migraine.
- Individualized patient factors are paramount in selecting the most effective migraine treatment.
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