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Updated: May 21, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

Risk factors for developing transient neonatal cholestasis.

Valerie Champion¹, Ricardo Carbajal, Jana Lozar

¹Service de Néonatologie, Hôpital Armand Trousseau, APHP, Université Pierre et Marie Curie, Paris, France.

Journal of Pediatric Gastroenterology and Nutrition

|June 12, 2012

Summary

Neonatal cholestasis, a complication of parenteral nutrition (PN), affects high-risk newborns. Small for gestational age (SGA) and neonatal surgery are significant additional risk factors for this condition.

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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Area of Science:

Neonatology
Pediatric Gastroenterology
Clinical Nutrition

Background:

Neonatal cholestasis is a critical concern in high-risk infants.
Identifying specific risk factors is crucial for early intervention and management.

Purpose of the Study:

To determine the incidence and characteristics of neonatal cholestasis.
To investigate additional risk factors beyond known ones.

Main Methods:

A prospective observational study of 460 neonates, divided into high- and low-risk groups.
High-risk criteria included preterm birth (<34 weeks), SGA, prolonged PN (>7 days), or surgery.
Weekly bilirubinemia monitoring in the high-risk group.

Main Results:

Cholestasis occurred in 13.7% of high-risk neonates, all receiving PN; none in the low-risk group.
Small for gestational age (SGA) and neonatal surgery were identified as independent risk factors (ORs 4.4 and 4.6, respectively).
Cholestasis correlated with severe neonatal conditions, longer PN duration, and increased macronutrient intake.

Conclusions:

Transient neonatal cholestasis is a complication associated with parenteral nutrition (PN).
Small for gestational age (SGA) and neonatal surgery are significant independent risk factors.
Current evidence does not support limiting intravenous protein intake in preterm infants.