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Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein
1Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
British Journal of Clinical Pharmacology
|January 1, 1990
Abstract:
Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.