Related Experiment Video
Updated: May 21, 2026
09:04
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
Nitroglycerin for management of retained placenta: a multicenter study.
Maria Bullarbo1, Hans Bokström, Håkan Lilja
1Department of Obstetrics and Gynecology, Södra Älvsborg Hospital, 501 82 Borås, Sweden.
Obstetrics and Gynecology International
|June 12, 2012
Summary
Sequential oxytocin and nitroglycerin for retained placenta showed a trend toward effectiveness, especially with prior clinical experience. No significant adverse effects were observed in this study.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
Background:
- Retained placenta is a significant obstetric complication.
- Current management often involves uterotonics like oxytocin.
Purpose of the Study:
- To evaluate the efficacy of sequential oxytocin and nitroglycerin for retained placenta management.
- To assess adverse effects of nitroglycerin in this context.
Main Methods:
- A randomized controlled trial involving 105 women with retained placenta.
- Sublingual nitroglycerin or placebo administered after initial oxytocin failure.
- Comparison of outcomes between nitroglycerin and placebo groups, with analysis stratified by prior clinical experience.
Main Results:
- A higher, though not statistically significant, success rate for placental detachment in the nitroglycerin group (37.3%) versus placebo (20.4%).
- In hospitals with prior experience, nitroglycerin success rate was 47.4% compared to 15.0% for placebo.
- No clinically significant adverse effects of nitroglycerin were reported.
Conclusions:
- Sequential oxytocin and nitroglycerin may offer a potential benefit for retained placenta, particularly with clinical experience.
- Further research with experienced clinicians is warranted to confirm efficacy and optimize use.
More Related Videos
Related Concept Videos
01:20Angina V: Nursing Management
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
01:26Angina IV: Management
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
01:28Acute Coronary Syndrome IV: Interprofessional Care
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
01:18Drug Delivery: Enteral Route
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drugs in...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:16Antianginal Drugs: Nitrates and β-Blockers
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...