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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
Published on: April 9, 2019
Pathophysiological implications of different bicuspid aortic valve configurations.
F A Kari1, F Beyersdorf, M Siepe
1Department of Cardiovascular Surgery, Heart Center Freiburg University, Hugstetter Stra β e 55, 79106 Freiburg, Germany.
Cardiology Research and Practice
|June 12, 2012
Summary
Bicuspid aortic valve (BAV) type may influence aortic media disease severity but not aneurysm location or extent. Some BAVs with raphe show more aggressive disease, suggesting varied pathophysiological mechanisms in BAV aortopathy.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Pathophysiology
Background:
- Bicuspid aortic valve (BAV) presents diverse configurations.
- Emerging evidence links BAV types to distinct aortic media disease substrates.
Purpose of the Study:
- To review current human and experimental data on BAV types and aortopathy.
- To explore the relationship between BAV morphology, aortic media disease, and aneurysm characteristics.
Main Methods:
- Review of recent human and experimental studies.
- Analysis of findings on BAV configurations and aortic pathology.
Main Results:
- BAV type appears linked to aortic media disease severity, not aneurysm location/extent.
- BAVs with raphe may exhibit more aggressive disease.
- Hemodynamic and hereditary factors likely contribute to BAV-associated aortopathy.
Conclusions:
- BAV type influences local aortic media disease.
- Aortopathy location and extent may be primarily heritable.
- Further research is needed to clarify BAV type's role in aortic complications.
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