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A case of follicular lymphoma associated with paraneoplastic cerebellar degeneration
Yayoi Shimazu1, Eiko N Minakawa, Momoko Nishikori
1Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Abstract:
Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned out to be paraneoplastic cerebellar degeneration, a subtype of PND that develops cerebellar symptoms, that was caused by follicular lymphoma. After chemotherapy, the patient attained sufficient improvement of cerebellar symptoms along with complete remission of lymphoma. Paraneoplastic cerebellar degeneration should be recognized as a rare complication of lymphoma as it is important to start proper treatment before the neurological symptoms become irreversible.
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