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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder

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Published on: September 6, 2024

Genes associated with autism spectrum disorder.

Xiaohong Li¹, Hua Zou, W Ted Brown

¹Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, United States. xiaohong.li@omr.state.ny.us

Brain Research Bulletin

|June 13, 2012

Summary

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component. This review explores candidate and rare genes implicated in ASD etiology, utilizing various genetic study methods.

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Area of Science:

Neurogenetics
Developmental Neuroscience

Background:

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder.
Characterized by social interaction, communication impairments, and repetitive behaviors.
Etiology is multifactorial with a strong genetic basis, yet mechanisms remain unclear.

Purpose of the Study:

To review current evidence on genetic factors contributing to ASD.
To discuss candidate genes and rare genes associated with ASD etiology.
To highlight the role of advanced genetic technologies in understanding autism.

Main Methods:

Review of molecular, cytogenetic, linkage, and association studies.
Inclusion of data from studies on autistic subjects.
Incorporation of findings from newer methods like whole-exome sequencing.

Main Results:

Evidence supports a strong genetic contribution to ASD.
Several candidate genes and rare genes are linked to ASD etiology.
Advanced genetic technologies are enhancing the understanding of autism's genetic underpinnings.

Conclusions:

ASD genetics are complex and multifactorial.
Ongoing research utilizing diverse genetic approaches is crucial.
New technologies are pivotal in unraveling the genetic basis of autism.