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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
An efficient synthesis of the 4'-epimer of 2-fluoronoraristeromycin
Quachel Bazile1, Tesfaye Serbessa, Junyan Zhong
1Elizabeth City State University, Department of Chemistry, Geology, and Physics Elizabeth city, NC 27909.
Tetrahedron Letters
|June 13, 2012
Abstract:
The 4'-epimer of 2-fluoronoraristeromycin was synthesized by employing bis-t-butoxycarbonyl (Boc) protected 2-fluoroadenine as a superior substrate for the Mitsunobu reaction with the appropriate cyclopentenol. Unlike the unsubstituted counterpart 2-fluoroadenine, this substrate is completely soluble in THF and resulted in a very good yield in the Mitsunobu coupling reaction as well as subsequent steps.

