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Updated: May 21, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Fetal-maternal interface: a chronicle of allogeneic coexistence
Josep-Maria Pujal1, Santiago Roura, Ana M Muñoz-Marmol
1ICREC Research Group, Health Sciences Research Institute Germans Trias i Pujol, Barcelona, Spain.
Abstract:
The existence of allogeneic cells within an individual has been demonstrated in multiple fields such as hematopoietic stem cell or solid organ transplantation, non-depleted blood transfusions and the most common form which is bidirectional maternal-fetal cell trafficking, whereby cells from the fetus pass through the placental barrier. In order to graphically illustrate this early natural phenomenon that initiates the journey of a child's cells within the mother's blood and other tissues, we used a new procedure in microscopy imaging generating Large Scale Panoramic Pictures (LSPP). This technique can also be extended to explore a broad diversity of experimental models.
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