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Updated: May 21, 2026

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Reusable Single Cell for Iterative Epigenomic Analyses
Published on: February 11, 2022
The NIH Roadmap Epigenomics Program data resource
1Division of Extramural Research & Training, National Institute of Environmental Health Sciences, 530 Davis Drive, Morrisville, NC 27709, USA. chadwickL@niehs.nih.gov
Epigenomics
|June 14, 2012
Summary
The National Institutes of Health (NIH) Roadmap Reference Epigenome Mapping Consortium offers a valuable resource of human epigenome maps. This data aids researchers in understanding epigenetics and its role in human diseases.
Area of Science:
- Epigenetics and genomics
- Human disease research
Background:
- The NIH Roadmap Reference Epigenome Mapping Consortium is creating a comprehensive database of epigenome-wide maps.
- These maps cover diverse human primary cells and tissues, providing a rich dataset for scientific inquiry.
Purpose of the Study:
- To describe the key features of the consortium's websites, including data access, protocols, and analysis tools.
- To highlight how this resource can advance human disease research.
Main Methods:
- Development of genome-wide epigenetic maps.
- Creation of user-friendly websites for data access and analysis.
Main Results:
- Availability of extensive epigenome data.
- Provision of diverse options for data viewing and analysis.
Conclusions:
- The consortium's resource facilitates immediate and future human disease research.
- This unique epigenomic data will inform our understanding of various health conditions.
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Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

