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Updated: Apr 20, 2026

Reusable Single Cell for Iterative Epigenomic Analyses
Published on: February 11, 2022
Community resources and technologies developed through the NIH Roadmap Epigenomics Program
John S Satterlee1, Andrea Beckel-Mitchener, Kim McAllister
1Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, NIH, MSC 9555, Bethesda, MD, 20892-9555, USA, satterleej@nida.nih.gov.
Abstract:
This chapter describes resources and technologies generated by the NIH Roadmap Epigenomics Program that may be useful to epigenomics researchers investigating a variety of diseases including cancer. Highlights include reference epigenome maps for a wide variety of human cells and tissues, the development of new technologies for epigenetic assays and imaging, the identification of novel epigenetic modifications, and an improved understanding of the role of epigenetic processes in a diversity of human diseases. We also discuss future needs in this area including exploration of epigenomic variation between individuals, single-cell epigenomics, environmental epigenomics, exploration of the use of surrogate tissues, and improved technologies for epigenome manipulation.
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