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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Community resources and technologies developed through the NIH Roadmap Epigenomics Program.

John S Satterlee1, Andrea Beckel-Mitchener, Kim McAllister

  • 1Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, NIH, MSC 9555, Bethesda, MD, 20892-9555, USA, satterleej@nida.nih.gov.

Methods in Molecular Biology (Clifton, N.J.)
|November 26, 2014
PubMed
Summary
This summary is machine-generated.

The NIH Roadmap Epigenomics Program provides valuable resources and technologies, including reference epigenome maps and novel epigenetic discoveries, to advance disease research. Future directions focus on epigenomic variation, single-cell studies, and environmental influences.

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Area of Science:

  • Epigenomics and disease research

Background:

  • The National Institutes of Health (NIH) Roadmap Epigenomics Program has generated significant resources.
  • These resources are crucial for understanding epigenetics in various human diseases, including cancer.

Purpose of the Study:

  • To highlight the utility of NIH Roadmap Epigenomics Program resources for researchers.
  • To discuss advancements in epigenetics, including new technologies and disease associations.

Main Methods:

  • Development of novel technologies for epigenetic assays and imaging.
  • Generation of reference epigenome maps across diverse human cell types and tissues.
  • Identification of new epigenetic modifications and their roles in disease.

Main Results:

  • Creation of comprehensive reference epigenome maps for human cells and tissues.
  • Advancement in epigenetic assay and imaging technologies.
  • Enhanced understanding of epigenetic processes in human diseases.

Conclusions:

  • The NIH Roadmap Epigenomics Program offers valuable tools for epigenomics research.
  • Future research should address individual epigenomic variation, single-cell epigenomics, and environmental impacts.
  • Improved technologies for epigenome manipulation are needed.