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Updated: Jun 5, 2025
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Accelerating evidence generation: Addressing critical challenges and charting a path forward
Jeeyon G Rim1,2, Jennifer G Jackman2, Christoph P Hornik2,3
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Journal of Clinical and Translational Science
|December 10, 2024
Summary
Drug development needs efficient evidence generation to lower costs and improve public health. Leaders convened to realign incentives, making clinical trials faster, more inclusive, and cost-effective for equitable healthcare.
Area of Science:
- Health Services Research
- Clinical Trials Methodology
- Health Economics
Background:
- Rising healthcare costs and aging populations necessitate efficient evidence generation for medical therapies.
- Current drug development and clinical trial processes are expensive and inefficient for all stakeholders.
- Existing inefficiencies in clinical research hinder advancements in equitable healthcare delivery and outcomes.
Purpose of the Study:
- To explore realignment of incentive structures in drug development and healthcare.
- To accelerate evidence generation addressing critical public health needs.
- To identify strategies for making clinical trials faster, more inclusive, and efficient.
Main Methods:
- Convened leaders from academia, industry, government, patient advocacy, and nonprofits.
- Facilitated discussions on incentive structures and research practices.
- Identified key themes impacting clinical trial efficiency and equity.
Main Results:
- Competing research priorities and incentives hinder progress.
- Inadequate patient representation in clinical trials limits generalizability.
- Opportunities exist to leverage technology and infrastructure for better trial design.
- Heightened transparency and accountability are needed in research practices.
Conclusions:
- Current clinical research enterprise is inefficient and costly.
- Inefficiencies amplify health disparities and evidence gaps.
- Addressing these challenges can lead to faster, more inclusive, and equitable clinical trials across diverse populations and settings.
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