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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Current Trends in Nursing II01:30

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Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
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Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Sanger Sequencing01:57

Sanger Sequencing

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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The Evidence for Evolution02:55

The Evidence for Evolution

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Updated: Jun 5, 2025

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
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Accelerating evidence generation: Addressing critical challenges and charting a path forward.

Jeeyon G Rim1,2, Jennifer G Jackman2, Christoph P Hornik2,3

  • 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Journal of Clinical and Translational Science
|December 10, 2024
PubMed
Summary
This summary is machine-generated.

Drug development needs efficient evidence generation to lower costs and improve public health. Leaders convened to realign incentives, making clinical trials faster, more inclusive, and cost-effective for equitable healthcare.

Keywords:
Healthcare deliveryclinical trialsdrug developmentpatient advocacypopulation healthpublic health

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Area of Science:

  • Health Services Research
  • Clinical Trials Methodology
  • Health Economics

Background:

  • Rising healthcare costs and aging populations necessitate efficient evidence generation for medical therapies.
  • Current drug development and clinical trial processes are expensive and inefficient for all stakeholders.
  • Existing inefficiencies in clinical research hinder advancements in equitable healthcare delivery and outcomes.

Purpose of the Study:

  • To explore realignment of incentive structures in drug development and healthcare.
  • To accelerate evidence generation addressing critical public health needs.
  • To identify strategies for making clinical trials faster, more inclusive, and efficient.

Main Methods:

  • Convened leaders from academia, industry, government, patient advocacy, and nonprofits.
  • Facilitated discussions on incentive structures and research practices.
  • Identified key themes impacting clinical trial efficiency and equity.

Main Results:

  • Competing research priorities and incentives hinder progress.
  • Inadequate patient representation in clinical trials limits generalizability.
  • Opportunities exist to leverage technology and infrastructure for better trial design.
  • Heightened transparency and accountability are needed in research practices.

Conclusions:

  • Current clinical research enterprise is inefficient and costly.
  • Inefficiencies amplify health disparities and evidence gaps.
  • Addressing these challenges can lead to faster, more inclusive, and equitable clinical trials across diverse populations and settings.