Healing of fresh extraction sockets filled with bioactive glass particles: histological findings in humans
Related Experiment Video
Updated: May 21, 2026
The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
Emanuele Clozza1, Maurizio Pea, Fabio Cavalli
1Resident, Ashman Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY, USA Head, Department of Pathology, Ospedale Orlandi, Bussolengo, Verona, Italy Director, Research Unit of Paleoradiology and Allied Sciences, Ospedali Riuniti di Trieste, Trieste, Italy R&D manager, Inion Oy, Tampere, Finland Full professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy Assistant professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy.
Purpose:
The aim of the present study was to histologically evaluate fresh human sockets filled with bioactive glass after 6 months of healing.
Materials And Methods:
In 13 patients, 32 single extraction sites in the anterior area underwent socket ridge preservation procedure (RPP) with a bioactive glass (BioRestore™, Inion Oy, Tampere, Finland). At implant installation, 22 bone cores were trephined out and processed for histomorphometric and immunohistochemical analysis.
Results:
Newly formed immature bone around residual particles of bioactive glass was found in all 22 biopsies. The histomorphometry of the amount of bone, provisional matrix, and residual graft returned a mean ± SD value of 54 ± 31%, 37.9 ± 25.6%, and 8.1 ± 7.8, respectively, 6 months after RPP.
Conclusion:
The use of this grafting material in fresh extraction sockets appears to delay the healing processes of the alveolar bone; therefore, its indication as a material for RPP when implant placement is considered within 6 months after extraction should be revised.
