Aniridia
Related Experiment Video
Updated: May 21, 2026

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Melanie Hingorani1, Isabel Hanson, Veronica van Heyningen
1Ophthalmology, Hinchingbrooke Hospital, Cambridgeshire, UK.
Abstract:
Aniridia is a rare congenital disorder in which there is a variable degree of hypoplasia or the absence of iris tissue associated with multiple other ocular changes, some present from birth and some arising progressively over time. Most cases are associated with dominantly inherited mutations or deletions of the PAX6 gene. This article will review the clinical manifestations, the molecular basis including genotype-phenotype correlations, diagnostic approaches and management of aniridia.
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