Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies.

Brain pathology (Zurich, Switzerland)·2026

Same author

A tissue engineering approach to regenerate the cranial suture skeletal stem cell niche with a multicompartment biomaterial scaffold.

Bone research·2026

Same author

<i>Gli1<sup>+</sup></i> Cells Exhibit Clonogenicity and Slow-Cycling Features at the Temporomandibular Joint (TMJ) Enthesis-Condyle Interface.

International journal of molecular sciences·2026

Same author

Two-step Gelatin Embedding Preserves Fibrocartilage Morphology, Enthesis, and Cartilage Stain of Bone Joints.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026

Same author

Nanofibrous scaffolds for bone and cartilage regeneration.

Applied physics reviews·2026

Same author

Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice.

Biomedicines·2026

Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Computer-designed nano-fibrous scaffolds.

Laura A Smith¹, Peter X Ma

¹Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI, USA.

Methods in Molecular Biology (Clifton, N.J.)

|June 14, 2012

Summary

This summary is machine-generated.

Nano-fibrous scaffolds fabricated using phase separation and reverse solid freeform fabrication (SFF) enhance cell function and tissue regeneration. This advanced technique precisely controls scaffold architecture for improved cellular attachment and proliferation.

More Related Videos

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Published on: January 7, 2019

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Published on: June 18, 2014

Related Experiment Videos

Last Updated: May 21, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds

Published on: January 7, 2019

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Published on: June 18, 2014

Area of Science:

Biomaterials Science
Tissue Engineering
Nanotechnology

Background:

Nano-fibrous scaffolds mimic the extracellular matrix to support cell growth.
Traditional methods have limitations in creating complex scaffold architectures.
Precise control over scaffold features is crucial for effective tissue regeneration.

Purpose of the Study:

To investigate the fabrication of computer-designed nano-fibrous scaffolds.
To evaluate the benefits of these scaffolds for cell function and tissue regeneration.
To highlight the advantages of combining phase separation with reverse solid freeform fabrication (SFF).

Main Methods:

Utilizing thermally induced phase separation for nano-fiber formation.
Employing reverse solid freeform fabrication (SFF) for precise structural control.
Fabricating scaffolds with features across three orders of magnitude.

Main Results:

The combined technique allows for precise control over external shape and internal pore structure.
Nano-fibrous wall architecture promotes cellular attachment, proliferation, and differentiation.
Scaffolds demonstrate superior performance compared to traditional tissue engineering scaffolds.

Conclusions:

The integration of phase separation and reverse SFF offers a versatile method for creating advanced nano-fibrous scaffolds.
These scaffolds significantly enhance cellular functions essential for tissue regeneration.
This approach represents a promising advancement in the field of tissue engineering.