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Updated: May 21, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

Cerebral hemodynamic changes in stroke during sleep-disordered breathing.

Fabio Pizza¹, Martin Biallas, Ulf Kallweit

¹Department of Neurology, University Hospital Zürich, Zürich, Switzerland.

|June 14, 2012

Summary

This summary is machine-generated.

Sleep-disordered breathing (SDB) causes significant deoxygenation in acute stroke patients, particularly on the unaffected side. This brain hypoxia may worsen stroke outcomes, suggesting SDB treatment could be beneficial.

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Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

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Published on: November 19, 2020

Area of Science:

Neurology
Sleep Medicine
Medical Imaging

Background:

Sleep-disordered breathing (SDB) is linked to adverse outcomes in stroke patients.
Near-infrared spectroscopy (NIRS) can detect acute cerebral hemodynamic changes associated with SDB.

Purpose of the Study:

To investigate the acute cerebral hemodynamic effects of SDB in patients with middle cerebral artery stroke.
To analyze cerebral oxygenation and hemoglobin concentration changes during different types of apneas.

Main Methods:

Eleven patients with acute/subacute stroke and SDB underwent polysomnography and bilateral NIRS.
Cerebral oxygenation and hemoglobin levels were monitored during obstructive and central apneas.

Main Results:

NIRS revealed asymmetrical cerebral oxygenation and hemoglobin patterns during SDB.
Changes were more pronounced in the unaffected hemisphere compared to the affected hemisphere.
Brain tissue hypoxia was more severe during obstructive apneas than central apneas.

Conclusions:

SDB induces significant cerebral deoxygenation in acute/subacute stroke patients.
These hemodynamic changes may contribute to poorer stroke outcomes.
SDB treatment may offer a potential benefit for stroke management.