Sensor-Based Assessment of Morning Prospective Memory in Narcolepsy Type 1: Evidence from Children and Adult Cohorts

The aim of this study was to shed light on activity-based prospective memory performance in children and adult patients with narcolepsy type 1 (NT1) during the first sixty minutes after morning awakening. With reference to the children (C) sample, 21 C-NT1 patients and 20 healthy controls (C-HC) were enrolled; as regards adults (A), 31 A-NT1 patients and 51 A-HC were examined. Each participant used an actigraph for one week, being asked to press the event marker button at get-up time (prospective memory task-PMT). Computing the time interval between the get-up time and the moment the event marker button was pushed, no significant differences were observed in the children's groups. In contrast, in the adult groups, A-NT1 patients had a longer interval than A-HC. Moreover, the rate of compliant performers (those who remembered to push the event-marker button within 2 min of get-up time) and late performers was significantly different in adults only, with a low rate of compliant performers in A-NT1 patients. In C-NT1, a shorter cognitive inertia was associated with higher motor activity after awakening; in contrast, this association was not observed in A-NT1. Overall, the present pattern of results suggests that prospective memory performance is impaired only in NT1 adult patients.