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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Scanning Electron Microscopy01:07

Scanning Electron Microscopy

A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
Fundamental Principles
Accelerated...
Bioequivalence: Overview01:16

Bioequivalence: Overview

Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Updated: May 21, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

GeneView: a comprehensive semantic search engine for PubMed.

Philippe Thomas1, Johannes Starlinger, Alexander Vowinkel

  • 1Knowledge Management in Bioinformatics, Institute for Computer Science, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany.

Nucleic Acids Research
|June 14, 2012
PubMed
Summary
This summary is machine-generated.

Life scientists can now use GeneView, a semantic search engine, to find specific biomedical information more efficiently. GeneView overcomes challenges in searching large text repositories like MEDLINE by using annotated data and advanced text mining.

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Area of Science:

  • Biomedical Informatics
  • Computational Biology
  • Bioinformatics

Background:

  • Scientific literature growth outpaces curation efforts, hiding valuable knowledge in repositories like MEDLINE.
  • Ambiguous biomedical entity names (genes, chemicals, diseases) lead to inefficient information retrieval for life scientists.
  • Traditional search engines struggle with the scale and complexity of biomedical data.

Purpose of the Study:

  • To introduce GeneView, a novel semantic search engine designed for biomedical knowledge discovery.
  • To enhance information retrieval from large-scale biomedical text repositories.
  • To address the challenges posed by ambiguous entity names and information overload.

Main Methods:

  • GeneView is built on a semantically annotated version of PubMed abstracts and PubMed Central full texts.
  • Utilizes state-of-the-art text-mining tools for recognizing 10 entity classes and protein-protein interactions.
  • Employs semi-structured data representation to enable advanced search features.

Main Results:

  • GeneView provides efficient searching of biomedical knowledge, overcoming limitations of traditional engines.
  • Enables searching by unique database identifiers and ranking documents by mention frequency.
  • Contains annotations for over 194 million entities across 10 classes for approximately 21 million citations.

Conclusions:

  • GeneView offers a powerful semantic search solution for the biomedical domain.
  • Facilitates more precise and efficient access to hidden knowledge within scientific literature.
  • Represents a significant advancement in biomedical text mining and information retrieval.