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Updated: May 21, 2026

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement.

Klaus-Martin Schulte¹, Prakash Sinha, Nadia Talat

¹Department of Endocrine Surgery, King's College Hospital, King's Health Partners, London, UK. klaus-martin.schulte@nhs.net

BMJ Case Reports

|June 15, 2012

Summary

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This case report details a rare instance of hyaline vascular Castleman's disease presenting as an adrenal incidentaloma. Surgical resection achieved a cure, highlighting the importance of oncological principles in managing complex cases.

Area of Science:

Oncology
Pathology
Surgical Science

Background:

Adrenal incidentalomas require careful evaluation to rule out malignancy.
Castleman's disease is a rare lymphoproliferative disorder with distinct subtypes.
Hyaline vascular Castleman's disease typically presents as a localized form.

Observation:

A 78-year-old woman presented with B-symptoms and a 5 cm left adrenal incidentaloma.
Imaging suggested adrenal cancer, prompting radical surgical resection.
Histopathology revealed periadrenal hyaline vascular Castleman's disease with lymph node involvement and renal cortex infiltration.

Findings:

The tumor was confirmed as unicentric hyaline vascular Castleman's disease, not adrenal cancer.
Human herpesvirus 8 (HHV8) was negative.

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Last Updated: May 21, 2026

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

High Ki67 proliferation index (30-40%) was noted in germinal centers.

Locoregional lymph node involvement was present, indicating potential for multicentric spread.

Implications:

This case demonstrates the potential for unicentric Castleman's disease to involve adjacent structures and lymph nodes.
Complete oncological resection achieved a surgical cure with no recurrence at 3-year follow-up.
The findings underscore the importance of thorough histopathological examination for adrenal masses and the efficacy of radical surgery.