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Updated: May 21, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Profound and persistent painful paclitaxel peripheral neuropathy in a premenopausal patient
K I Quintyne1, P Mainstone, B McNamara
1Department of Medical Oncology, Mid-Western Cancer Centre, Mid-Western Regional Hospital, Limerick, Ireland. keithi.quintyne@hse.ie
Abstract:
The authors herein report the case of a 35-year-old woman undergoing adjuvant therapy for node positive breast cancer, who presented with short and rapidly progressive history of bilateral lower limb symptoms of peripheral neuropathy following therapy with paclitaxel. MRI of her neural axis revealed no leptomeningeal enhancement or focal metastatic lesions. Neurophysiological tests favoured toxic sensory axonal polyneuropathy. She remains symptomatic following discontinuation of therapy 20 months ago, and is under review with pain management.
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