Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-scale heart simulation augments the explainability of artificial intelligence-enabled electrocardiogram through provision of an electrocardiogram database labelled with cellular pathologies.

Computer methods and programs in biomedicine·2026
Same author

Low Expression Levels of Sodium Channels in the Right Ventricular Outflow Tract Underly the Genesis of the Characteristic Electrocardiogram Waveform in Brugada Syndrome.

Circulation journal : official journal of the Japanese Circulation Society·2025
Same author

Evaluation of the Efficacy and Accuracy of Super-Flexible Three-Dimensional Heart Models of Congenital Heart Disease Made via Stereolithography Printing and Vacuum Casting: A Multicenter Clinical Trial.

Journal of cardiovascular development and disease·2024
Same author

Transition mechanisms from atrial flutter to atrial fibrillation during anti-tachycardia pacing therapy.

Pacing and clinical electrophysiology : PACE·2023
Same author

Low-energy defibrillation using a base-apex epicardial electrode.

Pacing and clinical electrophysiology : PACE·2023
Same author

A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping.

Frontiers in physiology·2022

Related Experiment Video

Updated: May 21, 2026

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
07:12

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves

Published on: August 23, 2011

Bicuspid aortic valves undergo excessive strain during opening: a simulation study.

Susumu Katayama1, Nobuyuki Umetani, Toshiaki Hisada

  • 1Department of Human and Engineered Environmental Studies, School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

The Journal of Thoracic and Cardiovascular Surgery
|June 16, 2012
PubMed
Summary

The unique shape of the bicuspid aortic valve causes increased mechanical stress, leading to faster disease progression compared to other valve conditions. This highlights the role of morphology in bicuspid aortic valve disease.

More Related Videos

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Related Experiment Videos

Last Updated: May 21, 2026

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
07:12

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves

Published on: August 23, 2011

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
11:00

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Area of Science:

  • Cardiovascular biomechanics
  • Medical simulation modeling
  • Aortic valve disease research

Background:

  • Bicuspid aortic valve (BAV) is a common congenital heart defect.
  • Understanding BAV morphology's impact on disease progression is crucial.
  • Current models often simplify valve mechanics.

Purpose of the Study:

  • To investigate how bicuspid aortic valve (BAV) morphology influences disease progression.
  • To compare stress, strain, motion, and blood flow in BAV versus stenotic tricuspid aortic valves (TAV).
  • To utilize simulation models for analyzing mechanical factors in aortic valve disease.

Main Methods:

  • Developed finite element analysis (FEA) models of normal TAV, stenotic TAV, and BAV.
  • Simulated internal blood flow and leaflet motion using fluid-structure interaction (FSI).
  • Calculated stress, strain (curvature), and modified leaflet thickness to mimic disease progression.

Main Results:

  • BAV exhibited a higher transvalvular pressure gradient than stenotic TAV at similar areas.
  • Increased bending strain was observed in both BAV and stenotic TAV, but was greater in BAV.
  • Disease progression analysis showed accelerated stenosis severity solely in the BAV model.

Conclusions:

  • The distinct morphology of BAV generates significant bending strain on leaflets during ejection.
  • This elevated mechanical stress is a likely driver for the rapid progression of BAV disease.
  • Morphological factors are critical in understanding and predicting BAV disease severity.