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Small RNAs have a large impact: circulating microRNAs as biomarkers for human diseases

Matthew Weiland1, Xing-Hua Gao, Li Zhou

  • 1Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA.

RNA Biology
|June 16, 2012
PubMed

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MicroRNAs01:22

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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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Translational Regulation

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