Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Relative Risk

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...

Weighted Mean

Weighted Mean

While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...

Review and Preview

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Ratio Level of Measurement

Ratio Level of Measurement

The way a set of data is measured is called its level of measurement. Correct statistical procedures depend on a researcher being familiar with levels of measurement. For analysis, data are classified into four levels of measurement—nominal, ordinal, interval, and ratio.
A set of data measured using the ratio scale takes care of the ratio problem and provides complete information. Ratio scale data are like interval scale data, except they have a zero point and ratios can be calculated. For...

Methods of Medium Optimization

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease.

Gastroenterology·2022

Same author

Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium.

The lancet. Gastroenterology & hepatology·2022

Same author

CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease.

Gastroenterology·2022

Same author

Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis.

Journal of pediatric gastroenterology and nutrition·2022

Same author

Effects of Vascular Comorbidity on Cognition in Multiple Sclerosis Are Partially Mediated by Changes in Brain Structure.

Frontiers in neurology·2022

Same author

Hospitalization With Clostridioides difficile in Pediatric Inflammatory Bowel Disease: a Population-Based Study.

Journal of pediatric gastroenterology and nutrition·2022

Search research articles

Related Experiment Video

Updated: May 21, 2026

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

Relative importance measures for reprioritization response shift.

Lisa M Lix¹, Tolulope T Sajobi, Richard Sawatzky

¹School of Public Health, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada. lisa.lix@usask.ca

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation

|June 16, 2012

Summary

Response shift (RS) impacts health-related quality of life (HRQOL) interpretations. New methods detected changes in how patients with inflammatory bowel disease (IBD) prioritize HRQOL domains, especially those with active symptoms.

More Related Videos

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Related Experiment Videos

Last Updated: May 21, 2026

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

Health outcomes research
Psychometrics
Statistical methodology

Background:

Response shift (RS) can alter interpretations of longitudinal health-related quality of life (HRQOL) data.
Reprioritization RS, a change in the relative importance of HRQOL domains, requires novel statistical approaches for detection.

Purpose of the Study:

To introduce and evaluate new statistical methods for testing reprioritization response shift.
To assess changes in the relative importance of HRQOL domains over time in patients with inflammatory bowel disease (IBD).

Main Methods:

Employed descriptive discriminant analysis and logistic regression with bootstrap inference.
Two methods were proposed: one assessing changes in importance weights and another assessing changes in ranks.
Applied methods to the Manitoba Inflammatory Bowel Disease (IBD) Cohort Study (n=388), examining IBD Questionnaire (IBDQ) and SF-36 domains.

Main Results:

The IBDQ bowel symptoms and SF-36 bodily pain domains were most important for group discrimination.
Method 1 indicated reprioritization RS in IBDQ social functioning and SF-36 bodily pain and social functioning domains.
Method 2 did not detect significant changes in domain ranks.

Conclusions:

Patients with active IBD symptoms demonstrated altered self-evaluations regarding pain and social interactions compared to those without active symptoms.
Further research is necessary to compare the performance of the proposed RS detection methods across various data conditions.