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Related Concept Videos

Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

5-fluorouracil induced pericarditis.

Ammar Killu1, Malini Madhavan, Kavita Prasad

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

BMJ Case Reports
|June 16, 2012
PubMed
Summary
This summary is machine-generated.

5-fluorouracil (5-FU) can cause serious cardiac toxicity, presenting as angina or myocardial infarction. Prompt recognition of 5-FU cardiotoxicity, including rare myopericarditis, is crucial for patient outcomes.

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An Intact Pericardium Ischemic Rodent Model
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An Intact Pericardium Ischemic Rodent Model

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An Intact Pericardium Ischemic Rodent Model
07:15

An Intact Pericardium Ischemic Rodent Model

Published on: September 2, 2021

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • 5-fluorouracil (5-FU) is a widely used chemotherapy agent.
  • Cardiac toxicity is a known, albeit infrequent, adverse effect of 5-FU treatment.
  • The incidence of 5-FU cardiotoxicity varies, with estimates ranging from 1.2% to 18%.

Observation:

  • The commonest presentation of 5-FU cardiotoxicity is angina pectoris.
  • Other recognized cardiac manifestations include myocardial infarction, left ventricular dysfunction, arrhythmias, and sudden death.
  • An unusual case of myopericarditis mimicking myocardial infarction was observed.

Findings:

  • Cardiac toxicity from 5-FU is a potentially serious side effect.
  • A high index of suspicion and understanding of diverse cardiac manifestations are essential for prompt diagnosis.
  • Myopericarditis can present atypically, resembling myocardial infarction in the context of 5-FU therapy.

Implications:

  • Early identification and management of 5-FU-induced cardiotoxicity can improve patient prognosis.
  • Clinicians should consider cardiotoxicity in patients receiving 5-FU, even with atypical presentations.
  • Further research may elucidate mechanisms and improve monitoring strategies for 5-FU cardiotoxicity.