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Updated: May 21, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Brucellosis presenting as septic shock.

Mehandi Haran¹, Amit Agarwal, Yizhak Kupfer

¹Division of Pulmonary & Critical Care Medicine, Maimonides Medical Center, Medicine, Brooklyn, New York, USA.

BMJ Case Reports

|June 16, 2012

Summary

This summary is machine-generated.

This case highlights a rare instance of Brucellosis reactivating after 50 years, presenting as septic shock. Prolonged gentamicin therapy was required for remission in this elderly patient.

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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Area of Science:

Infectious Diseases
Microbiology
Internal Medicine

Background:

Brucellosis is a zoonotic bacterial infection with diverse clinical manifestations.
Typical symptoms include fever, malaise, weight loss, and bone pain.
Early diagnosis and appropriate antibiotic treatment are crucial for patient outcomes.

Observation:

A 76-year-old man presented with septic shock, characterized by high fever, tachycardia, and hypotension.
The patient had a history of Brucellosis in 1956, treated with tetracycline and streptomycin.
Blood cultures confirmed Brucella melitensis infection, despite no recent exposure history.

Findings:

The patient experienced a relapse of Brucellosis just two days after initial treatment.
Septic shock developed after a 50-year period of apparent quiescence.
A prolonged four-week course of gentamicin was necessary to achieve remission.

Implications:

This case underscores the potential for long-term latency and reactivation of Brucellosis.
It emphasizes the importance of considering Brucellosis in patients with recurrent infections or unexplained sepsis.
Extended antibiotic therapy may be required for complicated or relapsed Brucellosis cases.