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Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

WikiCell: a unified resource platform for human transcriptomics research.

Dongyu Zhao¹, Jiayan Wu, Yuanyuan Zhou

¹CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

Omics : a Journal of Integrative Biology

|June 19, 2012

Summary

This summary is machine-generated.

WikiCell offers a unified human transcriptome view using Expressed Sequenced Tags (ESTs). This database aids researchers in defining gene expression patterns and tissue differentiation via a human taxonomy model.

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Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

The human transcriptome is complex, requiring integrated data resources.
Existing databases may lack unified views or user-friendly access to gene expression data.

Purpose of the Study:

To introduce WikiCell, a novel database portal for a unified view of the human transcriptome.
To provide researchers with tools for accessing, curating, and analyzing human gene expression data.

Main Methods:

Development of WikiCell as a centralized database for human Expressed Sequenced Tags (ESTs).
Implementation of interactive modes for data access, curation, and submission.
Integration of a human taxonomy graph for organizing transcriptome data by physiological and pathological samples.
Conservation of Genbank EST data format for compatibility.

Main Results:

WikiCell provides a unified portal for human transcriptome data, currently comprising ESTs.
Users can interactively access, curate, submit, browse, query, upload, and download sequence data.
Gene information, including housekeeping genes, taxonomy location, and Gene Ontology (GO) descriptions, is available.
The database utilizes a human taxonomy model for sorting sequences by sample attributes.

Conclusions:

WikiCell serves as a valuable resource for understanding human gene expression patterns.
The database facilitates research on tissue differentiation based on a human taxonomy model.
WikiCell enhances accessibility and usability of human transcriptome data for the research community.