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Related Experiment Video

Updated: May 21, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Long-term cerebral imaging after pre-eclampsia.

A M Aukes1, J C De Groot, M J Wiegman

  • 1Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, the Netherlands.

BJOG : an International Journal of Obstetrics and Gynaecology
|June 19, 2012
PubMed
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Formerly pre-eclamptic women show increased cerebral white matter lesions (WMLs). This suggests pre-eclampsia may indicate early cerebrovascular damage and future cardiovascular risks.

Area of Science:

  • Neurology
  • Obstetrics
  • Cardiology

Background:

  • Formerly eclamptic women exhibit cerebral white matter lesions (WMLs) years post-pregnancy.
  • Pathophysiology may involve predisposition to cerebrovascular/cardiovascular disease or posterior reversible encephalopathy syndrome (PRES).

Purpose of the Study:

  • Assess WMLs presence and severity in formerly pre-eclamptic women.
  • Correlate WMLs with neurological symptoms during pregnancy and current cardiovascular risk factors.

Main Methods:

  • Retrospective cohort study comparing 73 formerly pre-eclamptic women with matched controls.
  • Cerebral MRI scans analyzed by a blinded neuroradiologist for WMLs.
  • Matched for age and time since index pregnancy.

Related Experiment Videos

Last Updated: May 21, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Main Results:

  • Formerly pre-eclamptic women had significantly more frequent (37% vs 21%) and severe WMLs.
  • Current hypertension and early-onset pre-eclampsia (<37 weeks) independently predicted WMLs.
  • WMLs were more severe in formerly pre-eclamptic women (mean 0.11 ml vs 0.015 ml).

Conclusions:

  • Pre-eclampsia may serve as a risk marker for early cerebrovascular damage.
  • Predisposition to cardiovascular and cerebrovascular disease in formerly pre-eclamptic women is a key factor.
  • The role of PRES history in WML development remains undetermined.