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10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Primary central nervous system lymphoma.
M Gelabert-González1, D Castro Bouzas, R Serramito-García
1Servicio de Neurocirugía, Complejo Hospitalario Universitario de Santiago de Compostela, Departamento de Cirugía, Universidad de Santiago de Compostela, Spain. miguel.gelabert@usc.es
Neurologia (Barcelona, Spain)
|June 19, 2012
Summary
Primary central nervous system lymphoma (PCNSL) is a rare brain tumor. This study found PCNSL often presents in the sixth decade with cognitive decline and headache, with a poor prognosis.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary central nervous system lymphoma (PCNSL) is a rare extranodal non-Hodgkin lymphoma.
- PCNSL accounts for approximately 4% of all primary brain tumors.
Purpose of the Study:
- To investigate the clinical characteristics, diagnosis, and prognosis of PCNSL.
- To identify factors influencing survival in PCNSL patients.
Main Methods:
- Retrospective review of 24 patients diagnosed with PCNSL between 1990 and 2010.
- Diagnosis confirmed via magnetic resonance imaging (MRI) and surgical confirmation.
- Data analyzed included patient demographics, clinical presentation, diagnostic methods, pathology, and survival outcomes.
Main Results:
- The median age at diagnosis was 59.3 years, with most patients being immunocompetent.
- Common presenting symptoms included cognitive decline (33.4%) and headache (25%).
- B-cell lymphoma was the most common pathology (91.6%). Mean survival was 12.8 months, with a 1-year survival rate of 37.5%.
Conclusions:
- PCNSL typically affects individuals in their sixth decade, presenting with cognitive decline and headache.
- A single intracranial lesion was observed in 75% of cases.
- Preoperative clinical status emerged as the most critical prognostic factor for survival.
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