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Whole Vitreous Humor Dissection for Vitreodynamic Analysis
Published on: May 24, 2015
Postmortem biochemistry performed on vitreous humor after postmortem CT-angiography
Silke Grabherr1, Christèle Widmer, Katia Iglesias
1University Center of Legal Medicine, Lausanne-Geneva, Rue du Bugnon 21, 1011 Lausanne, Switzerland.
Legal Medicine (Tokyo, Japan)
|June 19, 2012
Summary
Postmortem angiography using Angiofil® and paraffin oil does not significantly alter vitreous humor biochemistry. This finding supports its use in forensic pathology without compromising toxicological analysis.
Area of Science:
- Forensic Pathology
- Postmortem Imaging
- Clinical Chemistry
Background:
- Postmortem angiography is a valuable tool in forensic pathology.
- Concerns exist regarding contrast agent interference with postmortem analyses.
- Evaluating contrast agent impact on biochemical results is crucial.
Purpose of the Study:
- To assess the effect of Angiofil® and paraffin oil contrast agent on postmortem vitreous humor biochemistry.
- To determine if contrast injection influences key biochemical markers.
Main Methods:
- Vitreous humor samples were collected from 50 postmortem angiography cases and 50 controls.
- Biochemical analysis included glucose, urea, creatinine, 3-β-hydroxybutyrate, sodium, and chloride.
- Comparison of results between contrast-injected and control groups.
Main Results:
- Variations in biochemical values were noted between sequential samples within each group.
- These intra-group differences were not clinically significant.
- No clinically relevant impact of the contrast agent mixture on vitreous humor analytes was observed.
Conclusions:
- The contrast agent Angiofil® mixed with paraffin oil does not significantly affect postmortem vitreous humor biochemical analysis.
- This supports the safe use of this contrast agent in forensic postmortem angiography.
- Results indicate reliable biochemical data can be obtained post-angiography.
