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Updated: May 21, 2026

Mouse Models of Periventricular Leukomalacia
Published on: May 18, 2010
Periventricular leukomalacia is decreasing in Japan
Tokio Sugiura1, Tatenobu Goto, Hiroko Ueda
1Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. tokio@med.nagoya-cu.ac.jp
Periventricular leukomalacia (PVL), a cause of cerebral palsy in preterm infants, has significantly decreased in Japan. A 2007 survey found PVL prevalence lower than in previous decades, indicating improved outcomes for premature infants.
Area of Science:
- Neonatal neurology
- Pediatric neurology
- Developmental neuroscience
Background:
- Periventricular leukomalacia (PVL) is the primary cause of cerebral palsy in preterm infants.
- Understanding the epidemiological trends of PVL and cerebral palsy is crucial for public health initiatives.
Purpose of the Study:
- To determine the prevalence of periventricular leukomalacia (PVL) and cerebral palsy in Japan.
- To analyze trends in PVL prevalence over time in a Japanese cohort.
Main Methods:
- A nationwide survey was conducted on preterm infants born in 2007 with gestational ages less than 33 weeks.
- Diagnosis of PVL was confirmed using ultrasound and magnetic resonance imaging (MRI).
- Cerebral palsy was diagnosed clinically.
Main Results:
- In 2007, the prevalence of PVL was 2.7% by ultrasound and 3.3% by MRI.
- The prevalence of cerebral palsy was 4.3% in the surveyed cohort.
- Compared to previous studies (1990-1999), PVL prevalence has significantly decreased.
Conclusions:
- The prevalence of periventricular leukomalacia (PVL) has significantly declined in Japan.
- This decrease suggests potential improvements in neonatal care and outcomes for preterm infants.
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