Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthetic germ granules reveal a direct role of Vasa/DDX4 in RNA localization and translational activation.

bioRxiv : the preprint server for biology·2026
Same author

GCL pruning of PIP3 establishes the soma-germline boundary.

bioRxiv : the preprint server for biology·2026
Same author

Origin and establishment of the germline in Drosophila melanogaster.

Genetics·2025
Same author

GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer.

bioRxiv : the preprint server for biology·2025
Same author

Boosting the toolbox for live imaging of translation.

RNA (New York, N.Y.)·2024
Same author

Publisher Correction: How germ granules promote germ cell fate.

Nature reviews. Genetics·2024
Same journal

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.

Cell stem cell·2026
Same journal

Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.

Cell stem cell·2026
Same journal

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation.

Cell stem cell·2026
Same journal

Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment.

Cell stem cell·2026
Same journal

ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury.

Cell stem cell·2026
Same journal

ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Germline stem cells: origin and destiny.

Ruth Lehmann1

  • 1Howard Hughes Medical Institute; Skirball Institute, The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Cell Stem Cell
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Germline stem cells ensure genome transmission across generations. Their function is regulated by complex interactions with the niche and environment, ensuring adult germline maintenance.

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Experiment Videos

Last Updated: May 21, 2026

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Genetics

Background:

  • Germline stem cells are crucial for transmitting genetic material to offspring.
  • Recent research has uncovered mechanisms regulating germ cell development and adult stem cell maintenance.
  • The stem cell niche and environmental factors significantly influence germline stem cell activity.

Purpose of the Study:

  • To provide an overview of regulatory mechanisms governing germline stem cells.
  • To highlight the complexity and diversity of these regulatory processes.
  • To illustrate how niche and environmental interactions modulate stem cell function.

Main Methods:

  • This is a perspective piece, not an experimental study.
  • It synthesizes existing research and literature.
  • Examples of regulatory mechanisms are discussed.

Main Results:

  • Germline stem cell regulation involves intricate interactions.
  • Both the stem cell niche and external environment play critical roles.
  • Diverse mechanisms contribute to germline stem cell maintenance and function.

Conclusions:

  • Germline stem cell regulation is multifaceted.
  • Understanding these complex interactions is vital for reproductive health and genetics.
  • Further research will continue to elucidate these essential biological processes.