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Updated: May 21, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
Collagen I confers gamma radiation resistance
E Azorin1, P R González-Martínez, J Azorin
1Technology Research Management, Nuclear Research National Institute, Dr Nabor Carrillo Flores, Carr México-Toluca S/N La Marquesa, 52750 Ocoyoacac, Mexico. erica.azorin@inin.gob.mx
Abstract:
The effect of collagen on the response of somatomammotroph tumor cells (GH3) to gamma, radiation therapy was studied in vitro. After incubating confluent GH3 cell monolayers in a serum-free, maintaining medium, either with or without collagen, the monolayers were irradiated with 137Cs, gamma radiation. Collagen reduces cell mortality via ERK1/2 activation, abolishing gamma radiation, cell death, and promotes cell invasion when acting in synergy with collagen and in association with the, MAPK/ERK1/2 signaling pathway activation. The presence of collagen in somatomammotroph tumors, confers resistance to radiation.
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