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Related Experiment Video

Updated: May 21, 2026

Automated Quantification and Analysis of Cell Counting Procedures Using ImageJ Plugins

Automated Quantification and Analysis of Cell Counting Procedures Using ImageJ Plugins

Published on: November 17, 2016

Clinical factors influencing corrected count increment.

Shamee Shastry¹, Rajendra Chaudhary

¹Department of Transfusion Medicine in Kasturba, Medical College, Manipal University, Manipal, India.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|June 19, 2012

Summary

This summary is machine-generated.

Platelet transfusion refractoriness is a clinical challenge. This study found splenomegaly and anti-platelet drugs significantly impact corrected count increment in patients receiving platelet transfusions.

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Area of Science:

Hematology
Transfusion Medicine

Background:

Refractoriness to platelet transfusions presents a significant clinical challenge, impacting patient outcomes.
Understanding factors influencing platelet transfusion effectiveness is crucial for optimizing patient care.

Purpose of the Study:

To investigate patient characteristics associated with corrected count increment in platelet transfusions.
To identify key factors contributing to refractoriness in patients receiving apheresis platelet units.

Main Methods:

A study involving 161 apheresis platelet units transfused to 40 patients with diverse clinical diagnoses.
Logistic regression analysis was employed to determine the influence of various patient factors on refractoriness.

Main Results:

The median corrected count increment was 7344/mm(3), with a 22.82% platelet recovery.
Splenomegaly and the use of anti-platelet drugs were identified as statistically significant factors influencing refractoriness.
While fever, bleeding, sepsis, disseminated intravascular coagulation, and cyclosporine use were more frequent in refractory patients, they did not reach statistical significance.

Conclusions:

Splenomegaly and anti-platelet drug use are significant predictors of refractoriness to platelet transfusions.
Further research may be warranted to explore the non-statistically significant factors in larger cohorts.